Stimulation of Guanylyl Cyclase-D by Bicarbonate
نویسندگان
چکیده
منابع مشابه
Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate.
Atmospheric CO(2) is an important environmental cue that regulates several types of animal behavior. In mice, CO(2) responses of the olfactory sensory neurons (OSNs) require the activity of carbonic anhydrase to catalyze the conversion of CO(2) to bicarbonate and the opening of cGMP-sensitive ion channels. However, it remains unknown how the enhancement of bicarbonate levels results in cGMP pro...
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The GTP analog 5’-guanylyl-imidodiphosphate (Gpp(NH)p) caused marked stimulation of basal and catecholamine (isoproterenol)-sensitive adenylate cyclase from canine myocardium, frog erythrocytes and rat paraovarian fat. The combination of Gpp(NH)p (1OV M) and isoproterenol (10e4 M) produced activation of adenylate cyclase equal to (fat) or significantly greater than (heart, erythrocytes) that st...
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Results In vitro kinase assays revealed that the α1, but not the β1, subunit of sGC is a PKG substrate and that the phosphorylation site is located within the first 360 residues of the α1. A constitutively active form of PKG stimulated incorporation of 32P into the α1 subunit in vivo. In addition, PKG could be detected in sGC immunoprecipitates, suggesting that the two proteins interact in cell...
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Nitric oxide (NO)-sensitive guanylyl-cyclase (GC) is the most important receptor for the signaling molecule NO. Activation of the enzyme is brought about by binding of NO to the prosthetic heme group. By monitoring NO-binding and catalytic activity simultaneously, we show that NO activates GC only if the reaction products of the enzyme are present. NO-binding in the absence of the products did ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2009
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi900441v